|Thesis abstract: |
Time-correlated Single-Photon Counting (TCSPC) technique is a powerful investigation tool in life-science and medical research, such as Fluorescence Lifetime Imaging Microscopy (FLIM), Diffuse Optical Tomography (DOT) and Forster Resonance Energy Transfer (FRET). In order to reach the highest performance, TCSPC technique requires both excellent single-photon detectors and time measurement instrumentation having both picosecond resolution and extremely high linearity. My research activity aims at developing and characterizing new electronic instrumentation for high performance time measurement, starting from a single channel system and moving towards multichannel systems. These instruments are thus exploited in different scientific applications based on TCSPC technique.