In the last few decades, the ability to acquire high frame-rate (higher than standard video-rate), two- (2D) and three-dimensional (3D) movies of very faint specimen and fast-moving objects has become more and more important in many fields, like ambient surveillance, road safety, identification of people and objects, gaming, but also in biomedical imaging, time-resolved spectroscopy and studies on physics of materials. Aim of the project is the development of CMOS SPAD (Single-Photon Avalanche Diode) cameras able to acquire such videos, both in 2D and 3D mode, based on the Time-of-Flight technique, i.e. exploiting the measurement of the photon arrival time, and to use them in real scientific applications. Such CMOS SPAD imagers will provide both high framerate and single-photon sensitivity in the visible and near-infrared wavelength range, and will measure photon-timing with few hundreds of ps resolution and precision. Time-of-flight technique will also make it possible to move from the field of depth-resolved 3D ranging to other scientific markets like Raman Spectroscopy, Fluorescence Lifetime Imaging Microscopy, and so on. In fact in all those applications requiring to detect time-resolved maps of single-photon events, e.g., in biological imaging.